I am currently developing a utility for the PC game Diablo 3. I would like to use IM to extract what are called "item cards" from screenshots taken of the game. Here is an example of a typical screenshot of a user's inventory, with an item card:

The item card is directly next to the mouse cursor in the screenshot. I've viewed the background removal/masking page and I'm a little confused about how best to go about this. There was a similar utility created using very small corner samples from item cards that is no longer functioning, so I think that may be one of the best ways to go about this.
Important details:
- Item cards vary in height, but never in width
- Cards will always be within a small radius of the mouse cursor, which never varies in size, shape, or color
- Screenshots will not be .jpg, I simply converted the above example for ease of uploading
- Because I am creating this program for a potentially large userbase, the more versatile the trimming method, the better. Slight differences in resolution or gamma settings might produce problems.